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KMID : 0351619740150020301
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Kyungpook Medical Journal
1974 Volume.15 No. 2 p.301 ~ p.305
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Influence of Time Factor on Cell Cycle of Liver Cell
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張性翼/Sung, Ik Chang:Kang, Joo
朱剛/李壽廣/Lee, Su Kwang/Yoon, Kun Ho
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Abstract
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It is very important to set the adquate experimental time in the measurement of cell cycle.
According to our laboratory data of experimental time there are many variations in the results of data and these variations teem to have relation with circadian rhythm.
The animals were divided into four experimental groups : A M injection, P M injection, A M sacrificed, and P M sacrificed groups.
^(3)H-thymidine was introduced into one day postnatal male chicks of Shaver species and auloradiography was carried out on the liver cell.
The results were summurized
1. The cell cycles of liver cells in four experimental groups revealed distinct circadian rhythmicity.
2. The durations of T_(G) of A M and P M injection groups, and sacrifice groups were 110.6, 83.0, 239.0 and 530.0 hours respectively.
3. The S phase was about 7 hours in injection groups and about 10 hours in sacrifice groups.
4. The G2 phases were 2-3 hours in all the experimental groups.
5. The durations of G_(1) phase of A M and P M injection and sacrifice groups were 225.0 and 516.0 hours respectively.
6. The labelling indices of A M and P M injection and sacrifice groups were 6.6, 8.4, 4.4, and 2.0% respectively.
7. Circadian variation was most distinct in G_(1) phase and S phase showed remarkable circadian variation.
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